Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 926)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0168370	0.0998211	0.8676686
Weighted median	23	0.0347843	0.0547531	0.5252372
Inverse variance weighted	23	0.0292329	0.0390156	0.4537003
Simple mode	23	0.0394766	0.0906175	0.6673425
Weighted mode	23	0.0314318	0.0657055	0.6371034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.56170	21	0.6765469
Inverse variance weighted	17.81311	22	0.7170096

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028291	0.0056424	0.621298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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