Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 925)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1355877	0.1174121	0.2611435
Weighted median	23	0.0593866	0.0580833	0.3065727
Inverse variance weighted	23	0.0044812	0.0463805	0.9230288
Simple mode	23	-0.0842443	0.1128664	0.4633236
Weighted mode	23	0.0479655	0.0688976	0.4936027

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.05429	21	0.1127041
Inverse variance weighted	31.09045	22	0.0942795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080513	0.0066367	0.2385471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009424	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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