Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 924)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0260963	0.0998199	0.7963051
Weighted median	23	-0.0147155	0.0589459	0.8028624
Inverse variance weighted	23	0.0187206	0.0390157	0.6313531
Simple mode	23	-0.0356097	0.0969987	0.7170409
Weighted mode	23	-0.0356097	0.0744569	0.6371844

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.48244	21	0.6183028
Inverse variance weighted	18.72037	22	0.6625261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027522	0.0056423	0.630759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005743	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8