Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 923)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0563344	0.1005441	0.5812071
Weighted median	23	-0.0119313	0.0524627	0.8200935
Inverse variance weighted	23	0.0159850	0.0390158	0.6820211
Simple mode	23	-0.0061489	0.0835350	0.9419867
Weighted mode	23	-0.0160806	0.0603324	0.7923108

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.30546	21	0.4404305
Inverse variance weighted	21.92499	22	0.4643733

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044411	0.0056832	0.4432632

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006694	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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