Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 922)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0994079	0.1128392	0.3883058
Weighted median	23	0.0152913	0.0580746	0.7923160
Inverse variance weighted	23	-0.0303249	0.0435415	0.4861415
Simple mode	23	-0.0963208	0.1032283	0.3609048
Weighted mode	23	0.0211129	0.0829641	0.8014862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.83574	21	0.1763564
Inverse variance weighted	27.40109	22	0.1963871

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042424	0.0063783	0.5132025

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008486	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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