Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 921)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0010922	0.1321969	0.9934861
Weighted median	23	0.0490889	0.0549458	0.3716404
Inverse variance weighted	23	0.0096642	0.0504883	0.8482008
Simple mode	23	-0.0012608	0.0994253	0.9899966
Weighted mode	23	0.0307992	0.0638954	0.6345486

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.83246	21	0.0175950
Inverse variance weighted	36.84116	22	0.0246227

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005264	0.0074723	0.9445045

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011181	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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