Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 920)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1920014	0.0998206	0.0680845
Weighted median	23	-0.0354414	0.0531866	0.5051814
Inverse variance weighted	23	0.0224491	0.0390157	0.5650297
Simple mode	23	-0.0317292	0.0878304	0.7213550
Weighted mode	23	-0.0460257	0.0557300	0.4177448

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.60795	21	0.8420976
Inverse variance weighted	20.05565	22	0.5795584

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0131693	0.0056423	0.0296086

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006178	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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