Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 92)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0279118	0.0998199	0.7825037
Weighted median	23	0.0631764	0.0582924	0.2784597
Inverse variance weighted	23	0.0198161	0.0390155	0.6115202
Simple mode	23	-0.0371774	0.1038190	0.7236828
Weighted mode	23	0.0777872	0.0745146	0.3078588

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.23048	21	0.5067075
Inverse variance weighted	20.23824	22	0.5681402

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004972	0.0056423	0.9306229

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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