Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 919)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0015787	0.0998198	0.9875310
Weighted median	23	-0.0177648	0.0546193	0.7449933
Inverse variance weighted	23	-0.0793418	0.0390157	0.0419931
Simple mode	23	-0.0242741	0.0785682	0.7602618
Weighted mode	23	-0.0186824	0.0607310	0.7612608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.33778	21	0.4999651
Inverse variance weighted	21.05411	22	0.5173959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047754	0.0056423	0.4068918

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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