Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 918)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1167276	0.1116896	0.3078552
Weighted median	23	0.0757834	0.0552510	0.1701817
Inverse variance weighted	23	-0.0021402	0.0439876	0.9611954
Simple mode	23	0.0403398	0.0994767	0.6890118
Weighted mode	23	0.0749038	0.0706278	0.3004025

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.29122	21	0.1955617
Inverse variance weighted	27.96498	22	0.1768448

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072997	0.0063133	0.2605656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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