Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 917)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1053796	0.1198277	0.3891230
Weighted median	23	0.0194472	0.0570415	0.7331555
Inverse variance weighted	23	-0.0105601	0.0469471	0.8220283
Simple mode	23	0.0016202	0.1039417	0.9877039
Weighted mode	23	0.0345054	0.0679257	0.6165173

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.26208	21	0.0868468
Inverse variance weighted	31.85439	22	0.0799127

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071198	0.0067732	0.3051256

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009674	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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