Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 916)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0540852	0.0998194	0.5936385
Weighted median	23	0.0562595	0.0620563	0.3646247
Inverse variance weighted	23	0.0272996	0.0390153	0.4841051
Simple mode	23	-0.0133284	0.0980097	0.8930654
Weighted mode	23	-0.0194890	0.0925138	0.8350914

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.29054	21	0.5665079
Inverse variance weighted	19.37553	22	0.6220388

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016449	0.0056423	0.7735054

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000602	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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