Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 915)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0058706	0.1082015	0.9572436
Weighted median	23	-0.0295254	0.0566291	0.6021012
Inverse variance weighted	23	-0.0563338	0.0415711	0.1753794
Simple mode	23	-0.0122099	0.0968136	0.9007847
Weighted mode	23	-0.0224364	0.0612502	0.7176344

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.67452	21	0.2615359
Inverse variance weighted	24.97618	22	0.2982154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030989	0.0061161	0.6176525

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00082	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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