Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 914)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0283050	0.0998189	0.7795218
Weighted median	23	0.0033486	0.0621256	0.9570141
Inverse variance weighted	23	-0.0083197	0.0390153	0.8311390
Simple mode	23	-0.0154657	0.1057283	0.8850339
Weighted mode	23	0.0276827	0.1013709	0.7873364

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.95595	21	0.5240528
Inverse variance weighted	20.00327	22	0.5828354

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012273	0.0056423	0.8299031

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006075	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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