Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 913)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0043911	0.0998201	0.9653275
Weighted median	23	-0.0074267	0.0612230	0.9034491
Inverse variance weighted	23	-0.0249700	0.0390153	0.5221695
Simple mode	23	-0.1152063	0.1059028	0.2884360
Weighted mode	23	0.0304763	0.0903906	0.7391899

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.95094	21	0.5243705
Inverse variance weighted	20.05306	22	0.5797205

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018031	0.0056423	0.7524584

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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