Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 912)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0181662	0.1040862	0.8631204
Weighted median	23	-0.0206836	0.0566870	0.7152054
Inverse variance weighted	23	-0.0330902	0.0397706	0.4053939
Simple mode	23	0.1049997	0.0942395	0.2772270
Weighted mode	23	-0.0348170	0.0634799	0.5888904

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.83328	21	0.3529318
Inverse variance weighted	22.85966	22	0.4096901

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009165	0.0058834	0.8777

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007145	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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