Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 911)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1774354	0.0998201	0.0899641
Weighted median	23	-0.0525208	0.0545787	0.3359008
Inverse variance weighted	23	-0.0456985	0.0397057	0.2497610
Simple mode	23	-0.0200046	0.0928427	0.8313876
Weighted mode	23	-0.0521216	0.0590959	0.3873210

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.72937	21	0.4755745
Inverse variance weighted	22.78516	22	0.4139448

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080899	0.0056423	0.1663518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000732	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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