Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 910)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0330357	0.0998189	0.7439568
Weighted median	23	0.0547088	0.0546107	0.3164421
Inverse variance weighted	23	0.0596121	0.0390153	0.1265336
Simple mode	23	0.0448691	0.0989572	0.6546876
Weighted mode	23	0.1067962	0.0612306	0.0950885

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.37994	21	0.6878334
Inverse variance weighted	18.39676	22	0.6822222

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056895	0.0056423	0.3247529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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