Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 91)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0771118	0.1174123	0.5184678
Weighted median	23	0.0020729	0.0640905	0.9741985
Inverse variance weighted	23	-0.0602399	0.0448623	0.1793452
Simple mode	23	0.0556595	0.1147580	0.6324595
Weighted mode	23	0.0378540	0.0804576	0.6426400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.05523	21	0.1126819
Inverse variance weighted	29.08895	22	0.1423387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010361	0.0066368	0.8774318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009536	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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