Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 909)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1311795	0.1290234	0.3208626
Weighted median	23	-0.0951581	0.0618445	0.1238854
Inverse variance weighted	23	-0.0632753	0.0496525	0.2025353
Simple mode	23	-0.0952544	0.1293825	0.4693729
Weighted mode	23	-0.1350461	0.0875848	0.1373629

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.08638	21	0.0276249
Inverse variance weighted	35.63261	22	0.0332339

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00417	0.0072931	0.5735423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8