Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 908)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1024665	0.0998191	0.3163253
Weighted median	23	-0.0434147	0.0579119	0.4534549
Inverse variance weighted	23	-0.0364427	0.0390154	0.3502724
Simple mode	23	-0.0578225	0.0962515	0.5541500
Weighted mode	23	-0.0318689	0.0809307	0.6975338

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.82889	21	0.7791868
Inverse variance weighted	16.34527	22	0.7983880

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040545	0.0056423	0.480308

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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