Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 907)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0147750	0.1408278	0.9174388
Weighted median	23	0.0373612	0.0576450	0.5169044
Inverse variance weighted	23	0.0544928	0.0538981	0.3120007
Simple mode	23	-0.0080132	0.0874826	0.9278469
Weighted mode	23	0.0302350	0.0578866	0.6066711

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.79856	21	0.0044599
Inverse variance weighted	41.98543	22	0.0062764

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024391	0.0079602	0.7623134

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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