Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 906)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0755372	0.1139400	0.5145705
Weighted median	23	-0.0289064	0.0568166	0.6109160
Inverse variance weighted	23	-0.0181618	0.0443295	0.6820254
Simple mode	23	-0.0377113	0.0959058	0.6979474
Weighted mode	23	-0.0503058	0.0737017	0.5020097

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.36118	21	0.1592155
Inverse variance weighted	28.40118	22	0.1627640

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005754	0.0064404	0.3817548

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008671	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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