Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 905)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0390990	0.1218649	0.7515036
Weighted median	23	0.0030631	0.0580795	0.9579398
Inverse variance weighted	23	0.0090729	0.0466160	0.8456826
Simple mode	23	0.0909705	0.0876947	0.3108383
Weighted mode	23	0.0086847	0.0695727	0.9017926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.29954	21	0.0688152
Inverse variance weighted	31.40634	22	0.0880956

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018439	0.0068884	0.7915554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009533	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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