Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 904)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0029194	0.0998213	0.9769442
Weighted median	23	0.0188666	0.0554754	0.7337888
Inverse variance weighted	23	-0.0008672	0.0390158	0.9822666
Simple mode	23	0.0528688	0.0919729	0.5712385
Weighted mode	23	0.0220840	0.0625938	0.7275857

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.00352	21	0.6487814
Inverse variance weighted	18.00522	22	0.7056789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002325	0.0056424	0.9675158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005456	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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