Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 903)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0378700	0.1083137	0.7300962
Weighted median	23	0.0134101	0.0570054	0.8140200
Inverse variance weighted	23	0.0334883	0.0418634	0.4237442
Simple mode	23	0.1047823	0.0984811	0.2988752
Weighted mode	23	0.0283527	0.0647837	0.6659050

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.72567	21	0.2592410
Inverse variance weighted	25.32885	22	0.2816085

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043821	0.0061224	0.4820297

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007898	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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