Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 902)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1940520	0.1066839	0.0832105
Weighted median	23	-0.0237366	0.0589713	0.6873077
Inverse variance weighted	23	-0.0421184	0.0429992	0.3273248
Simple mode	23	0.0068621	0.1120948	0.9517389
Weighted mode	23	-0.0287795	0.0801756	0.7230504

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.98791	21	0.2936445
Inverse variance weighted	26.72244	22	0.2219586

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093303	0.0060303	0.1367468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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