Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 901)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1250644	0.0998197	0.2240131
Weighted median	23	0.0254632	0.0531999	0.6322006
Inverse variance weighted	23	-0.0531981	0.0398151	0.1815077
Simple mode	23	0.0145827	0.0850975	0.8655032
Weighted mode	23	0.0279105	0.0607228	0.6502862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.14674	21	0.5757273
Inverse variance weighted	22.91106	22	0.4067662

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.010947	0.0056422	0.0659038

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007505	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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