Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 900)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0082612	0.0998208	0.9348261
Weighted median	23	-0.0002214	0.0531338	0.9966750
Inverse variance weighted	23	-0.0086590	0.0390156	0.8243640
Simple mode	23	0.0405255	0.0810129	0.6218765
Weighted mode	23	0.0006487	0.0674659	0.9924149

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.57119	21	0.9229002
Inverse variance weighted	12.60510	22	0.9435933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010391	0.0056423	0.8556592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003835	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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