Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 90)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0467220	0.0998209	0.6445641
Weighted median	23	-0.0121179	0.0536493	0.8213007
Inverse variance weighted	23	-0.0407454	0.0390158	0.2963319
Simple mode	23	-0.0052281	0.0811067	0.9491866
Weighted mode	23	-0.0020494	0.0621221	0.9739807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.26254	21	0.7547234
Inverse variance weighted	17.16879	22	0.7539777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0053713	0.0056423	0.3519406

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005533	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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