Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 9)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0646149	0.1105430	0.5650962
Weighted median	23	0.0568015	0.0536500	0.2897171
Inverse variance weighted	23	0.0627366	0.0422133	0.1372318
Simple mode	23	0.0425341	0.0976654	0.6674367
Weighted mode	23	0.0557232	0.0634308	0.3891731

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75379	21	0.2159930
Inverse variance weighted	25.75421	22	0.2623846

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001153	0.0062484	0.985446

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8