Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 899)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0306712	0.0998205	0.7616690
Weighted median	23	-0.0140739	0.0575638	0.8068497
Inverse variance weighted	23	0.0302840	0.0390154	0.4376271
Simple mode	23	-0.0001202	0.0959502	0.9990115
Weighted mode	23	-0.0031876	0.0714822	0.9648336

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.26589	21	0.5044796
Inverse variance weighted	20.26591	22	0.5664105

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-2.38e-05	0.0056423	0.9966774

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006324	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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