Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 898)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0812400	0.0998205	0.4248574
Weighted median	23	-0.0130837	0.0579773	0.8214580
Inverse variance weighted	23	0.0078808	0.0390157	0.8399231
Simple mode	23	-0.0178411	0.1067961	0.8688506
Weighted mode	23	0.0002353	0.0795407	0.9976667

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.19823	21	0.6364275
Inverse variance weighted	18.83571	22	0.6554503

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004505	0.0056423	0.4335613

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000572	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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