Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 897)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0383047	0.0998210	0.7050332
Weighted median	23	0.0331165	0.0518981	0.5234044
Inverse variance weighted	23	0.0072477	0.0390158	0.8526314
Simple mode	23	-0.0493985	0.0829443	0.5575451
Weighted mode	23	0.0172147	0.0644783	0.7919678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.00757	21	0.5846544
Inverse variance weighted	19.25337	22	0.6296350

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027974	0.0056423	0.6251989

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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