Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 896)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0487973	0.1052489	0.6476776
Weighted median	23	0.0508175	0.0561047	0.3650623
Inverse variance weighted	23	0.0101438	0.0403434	0.8014760
Simple mode	23	0.0833305	0.0876725	0.3521968
Weighted mode	23	0.0666454	0.0623362	0.2966028

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.34617	21	0.3258028
Inverse variance weighted	23.52315	22	0.3727113

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023737	0.0059492	0.693924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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