Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 895)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0923679	0.1134147	0.4245408
Weighted median	23	-0.0231246	0.0568936	0.6844100
Inverse variance weighted	23	0.0125793	0.0443396	0.7766384
Simple mode	23	0.0010988	0.0987116	0.9912193
Weighted mode	23	-0.0316910	0.0582150	0.5916568

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.10934	21	0.1672634
Inverse variance weighted	28.41401	22	0.1623633

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064448	0.0064107	0.3261912

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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