Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 894)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0150517	0.0998210	0.8815825
Weighted median	23	0.0440871	0.0541844	0.4158454
Inverse variance weighted	23	-0.0158777	0.0390158	0.6840414
Simple mode	23	0.0775163	0.0919949	0.4085108
Weighted mode	23	0.0503523	0.0677250	0.4650564

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.45245	21	0.9724186
Inverse variance weighted	10.56577	22	0.9804090

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018994	0.0056424	0.7397388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003252	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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