Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 893)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2005875	0.1120500	0.0878583
Weighted median	23	-0.0679968	0.0562855	0.2270206
Inverse variance weighted	23	-0.0587369	0.0446746	0.1885868
Simple mode	23	-0.0614469	0.1065464	0.5699865
Weighted mode	23	-0.1096511	0.0734313	0.1495766

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.46203	21	0.1893769
Inverse variance weighted	28.84568	22	0.1493198

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087111	0.0063337	0.1835126

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009428	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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