Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 892)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1027590	0.1064742	0.3454748
Weighted median	23	0.0430986	0.0571340	0.4506435
Inverse variance weighted	23	0.0003985	0.0417021	0.9923764
Simple mode	23	0.0016543	0.0981674	0.9867065
Weighted mode	23	0.0135637	0.0804734	0.8676919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.89308	21	0.2982681
Inverse variance weighted	25.13423	22	0.2906986

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006286	0.0060184	0.3081523

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007616	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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