Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 891)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1267970	0.0998205	0.2178895
Weighted median	23	0.0047973	0.0575008	0.9335093
Inverse variance weighted	23	0.0336691	0.0402804	0.4032301
Simple mode	23	-0.0308974	0.0983838	0.7564421
Weighted mode	23	-0.0143442	0.0738921	0.8478604

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.39949	21	0.4960988
Inverse variance weighted	23.44966	22	0.3767225

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098542	0.0056423	0.0953409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007331	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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