Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 890)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1061175	0.0998206	0.2998176
Weighted median	23	-0.0062188	0.0549282	0.9098591
Inverse variance weighted	23	-0.0312218	0.0390159	0.4235754
Simple mode	23	-0.1423260	0.0953681	0.1498005
Weighted mode	23	0.0162145	0.0714617	0.8225982

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.80810	21	0.9446540
Inverse variance weighted	14.04244	22	0.8999662

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.008434	0.0056423	0.1498508

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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