Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 89)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0032908	0.0998210	0.9740125
Weighted median	23	0.0228133	0.0537952	0.6715089
Inverse variance weighted	23	0.0240882	0.0390157	0.5369726
Simple mode	23	0.0361909	0.0836134	0.6693471
Weighted mode	23	0.0146980	0.0638658	0.8201101

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.85421	21	0.7199048
Inverse variance weighted	16.90545	22	0.7685587

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012772	0.0056424	0.8231156

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005238	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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