Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 889)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1108233	0.0998207	0.2794540
Weighted median	23	-0.0102718	0.0565829	0.8559475
Inverse variance weighted	23	-0.0034963	0.0390156	0.9285940
Simple mode	23	-0.0108089	0.0861634	0.9013097
Weighted mode	23	-0.0214425	0.0629814	0.7367420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.05939	21	0.5813303
Inverse variance weighted	20.42389	22	0.5565428

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065909	0.0056423	0.2558496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006191	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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