Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 888)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0137046	0.0998204	0.8921076
Weighted median	23	0.0756368	0.0522898	0.1480393
Inverse variance weighted	23	0.0366772	0.0390156	0.3471842
Simple mode	23	0.0857499	0.0858947	0.3289819
Weighted mode	23	0.0830779	0.0607015	0.1849298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.87425	21	0.8292081
Inverse variance weighted	14.93677	22	0.8649373

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014107	0.0056423	0.8049946

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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