Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 887)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0251301	0.1045422	0.8123648
Weighted median	23	-0.1105795	0.0567484	0.0513439
Inverse variance weighted	23	-0.0745503	0.0409289	0.0685373
Simple mode	23	-0.0392941	0.0966215	0.6881718
Weighted mode	23	-0.0795715	0.0732525	0.2891218

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.03398	21	0.3421693
Inverse variance weighted	24.21100	22	0.3362671

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061214	0.0059092	0.3120314

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008443	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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