Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 886)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0654374	0.0998202	0.5192300
Weighted median	23	-0.0034034	0.0552762	0.9509042
Inverse variance weighted	23	-0.0236950	0.0390157	0.5436394
Simple mode	23	-0.0164060	0.0878521	0.8535718
Weighted mode	23	0.0258118	0.0771830	0.7412270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.32866	21	0.8061065
Inverse variance weighted	15.53507	22	0.8382715

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025634	0.0056423	0.654262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004819	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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