Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 885)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0915892	0.1107367	0.4174857
Weighted median	23	-0.0396454	0.0609982	0.5157286
Inverse variance weighted	23	-0.0144779	0.0433644	0.7384815
Simple mode	23	-0.0562934	0.1004488	0.5808568
Weighted mode	23	-0.0745497	0.0968870	0.4498095

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.84548	21	0.2124023
Inverse variance weighted	27.17822	22	0.2045357

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065136	0.0062594	0.3098881

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008277	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8