Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 884)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1277801	0.0998196	0.2144671
Weighted median	23	0.0800026	0.0542290	0.1401388
Inverse variance weighted	23	0.0487633	0.0390156	0.2113572
Simple mode	23	0.0718248	0.0786486	0.3710181
Weighted mode	23	0.0837898	0.0610190	0.1835329

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.39383	21	0.6239634
Inverse variance weighted	19.13345	22	0.6370741

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048524	0.0056423	0.3994959

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006271	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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