Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 883)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1135578	0.1355456	0.4115867
Weighted median	23	-0.0447161	0.0600151	0.4562227
Inverse variance weighted	23	-0.0772227	0.0518652	0.1365108
Simple mode	23	0.0060671	0.1210558	0.9604801
Weighted mode	23	-0.0608478	0.1003210	0.5503703

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.72362	21	0.0105883
Inverse variance weighted	38.88002	22	0.0145652

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022314	0.0076618	0.7737305

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012967	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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