Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 882)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0271738	0.0998198	0.7881046
Weighted median	23	0.0186574	0.0563141	0.7404104
Inverse variance weighted	23	0.0230990	0.0390154	0.5538185
Simple mode	23	-0.0674838	0.1011957	0.5117926
Weighted mode	23	-0.0434124	0.0863037	0.6199500

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.60520	21	0.7914073
Inverse variance weighted	15.60716	22	0.8348926

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002502	0.0056423	0.9650441

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8